D. B. Berezin, V. V. Makarov, S. A. Znoyko, V. E. Mayzlish, A. V. Kustov, “Aggregation of water soluble octaanionic phthalocyanines and their photoinactivation antimicrobial effect <i>in vitro</i>”, Mendeleev Commun., 2020, Volume 30, Issue 5,Pages <nobr>621

This article is cited in 21 papers

Communications

Aggregation of water soluble octaanionic phthalocyanines and their photoinactivation antimicrobial effect in vitro

D. B. Berezin^a, V. V. Makarov^a, S. A. Znoyko^a, V. E. Mayzlish^a, A. V. Kustov^ab

^a Research Institute of Macroheterocycles, Ivanovo State University of Chemistry and Technology, Ivanovo, Russian Federation
^b G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo, Russian Federation

Abstract: Aggregation of sulfophenylsulfanyl-substituted phthalocyanine and its aluminum complex has been investigated in aqueous solutions of DMF or nonionic surfactant Tween 80 by UV-VIS spectroscopy and DLS. Aluminum complex is less aggregated and 4.5 orders of magnitude stronger bound to the micelles of Tween 80 compared to a metal-free ligand. Under irradiation the phthalocyanine derivatives reveal a pronounced antimicrobial activity towards both Gram(+) and Gram(−) archive microflora in vitro.

Keywords: antimicrobial photodynamic therapy, photosensitizer, water soluble phthalocyanine, aggregation, nonionic surfactant, microorganisms photoinactivation.

Language: English

DOI: 10.1016/j.mencom.2020.09.023

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