L. Trifonov, K. Chumin, R. Gvirtz, M. Afri, E. E. Korshin, G. Cohen, A. Gruzman, “Novel sulfamoylbenzoates as antifungal agents against <i>Malassezia furfur</i>”, Mendeleev Commun., 2020, Volume 30, Issue 6,Pages <nobr>709

This article is cited in 2 papers

Communications

Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur

L. Trifonov^a, K. Chumin^b, R. Gvirtz^ab, M. Afri^a, E. E. Korshin^a, G. Cohen^b, A. Gruzman^a

^a Department of Chemistry, Bar-Ilan University, Bar-Ilan, Israel
^b The Skin Research Institute, The Dead-Sea and Arava Science Center, Masada, Israel

Abstract: Novel polyfunctional arenesulfonamides as potential fungicides were prepared in eight steps from 3-amino-5-bromobenzoic acid. Among them, methyl 3-bromo-2-nitro-5-(N-phenylsulfamoyl)benzoate exhibiting significant cytotoxic activity against Malassezia furfur is proposed as a lead for the development of drug candidates against skin diseases caused by the fungi, especially against seborrheic dermatitis.

Keywords: fungicides, medicinal chemistry, arenesulfonamides, Malassezia furfur, seborrheic dermatitis.

Language: English

DOI: 10.1016/j.mencom.2020.11.006

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