E. G. Korzhikova-Vlakh, N. N. Zashikhina, E. G. Stulova, A. Yu. Dzhuzha, V. A. Korzhikov-Vlakh, “Effect of L- or D,L-leucine content on self-assembly and properties of its amphiphilic copolymers with L-lysine”, Mendeleev Commun., 2024, Volume 34, Issue 3,Pages <nobr>365

Communications

Effect of L- or D,L-leucine content on self-assembly and properties of its amphiphilic copolymers with L-lysine

E. G. Korzhikova-Vlakh^ab, N. N. Zashikhina^b, E. G. Stulova^a, A. Yu. Dzhuzha^b, V. A. Korzhikov-Vlakh^a

^a Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
^b Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russian Federation

Abstract: Copolymers of l-lysine and l/d,l-leucine differing in amino acid composition were synthesized and characterized for their self-assembly into nanoparticles. The effect of polypeptide composition on critical aggregation concentration, hydrodynamic diameter of nanoparticles, their stability and cytotoxicity was explored and discussed.

Keywords: copolymers, lysine, leucine, amphiphilic polypeptides, self-assembly, critical aggregation concentration, nanoparticles.

Language: English

DOI: 10.1016/j.mencom.2024.04.017

	*Supplementary materials:*
		Supplementary_data_1.pdf	306.0 Kb