M. S. Oshchepkov, A. S. Semyonkin, A. O. Menkov, P. A. Melnikov, M. P. Valikhov, I. N. Solovieva, S. V. Tkachenko, J. A. Malinowskaya, “Microflow synthesis of fluorescent markers based on 1,8-naphthalimide for polylactide nanoparticles and bioimaging”, Mendeleev Commun., 2020, Volume 30, Issue 6,Pages <nobr>747

This article is cited in 4 papers

Communications

Microflow synthesis of fluorescent markers based on 1,8-naphthalimide for polylactide nanoparticles and bioimaging

M. S. Oshchepkov^a, A. S. Semyonkin^a, A. O. Menkov^a, P. A. Melnikov^b, M. P. Valikhov^b, I. N. Solovieva^a, S. V. Tkachenko^a, J. A. Malinowskaya^b

^a D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
^b V.P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Moscow, Russian Federation

Abstract: Two strategies for the synthesis of the new fluorescent markers based on 1,8-naphthalimide under classical conditions (in a flask) and in a microflow reactor are compared and contrasted. The microflow method provides higher purity of products, better productivity and production time. The resulting markers were used to obtain fluorescently labeled polylactide-based nanoparticles that can be used to study the distribution of polylactide nanoparticles as drug delivery vehicles within tissues and living organisms.

Keywords: microfluidic synthesis, fluorescent markers, polylactide, 1,8-naphthalimide, bioimaging.

Language: English

DOI: 10.1016/j.mencom.2020.11.019

	*Supplementary materials:*
		Supplementary_data_1.pdf	1.9 Mb