S. A. Gorbatov, D. Yu. Uvarov, A. M. Scherbakov, I. V. Zavarzin, Yu. A. Volkova, A. Romieu, “A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells”, Mendeleev Commun., 2020, Volume 30, Issue 6,Pages <nobr>750

This article is cited in 5 papers

Communications

A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells

S. A. Gorbatov^ab, D. Yu. Uvarov^a, A. M. Scherbakov^c, I. V. Zavarzin^a, Yu. A. Volkova^a, A. Romieu^b

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302, CNRS, Univ.Bourgogne
^c N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

Abstract: The development of effective methods for real-time monitoring of nitroreductase (NTR) activity is of great significance for medical diagnosis and cancer research. Here, we present a novel water-soluble BODIPY-based chemodosimeter (NBB) for imaging the hypoxic status of human non-small-cell lung cancer A549 cells. We assume that ‘on–off’ response of NBB is activated by the NTRmediated reductive release of meso-phenol BODIPY dye resulting in unusual fluorescence.

Keywords: BODIPY, fluorescent probe, hypoxia, lung cancer, nitroreductase.

Language: English

DOI: 10.1016/j.mencom.2020.11.020

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