L. M. Nguyen, H. H. Truong, V. N. Khrustalev, S. T. Truong, D. T. Nguyen, V. T. Tran, S. T. Mai, V. T. Tran, A. T. Le, “Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings”, Mendeleev Commun., 2020, Volume 30, Issue 6,Pages <nobr>753

This article is cited in 5 papers

Communications

Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings

L. M. Nguyen^ab, H. H. Truong^c, V. N. Khrustalev^cd, S. T. Truong^a, D. T. Nguyen^a, V. T. Tran^a, S. T. Mai^a, V. T. Tran^a, A. T. Le^a

^a Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Hoan Kiem, Hanoi, Vietnam
^b Faculty of Pharmacy, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen City, Vietnam
^c Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation
^d N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Six novel phane-structured diazacrowns containing γ-piperidone and pyridine rings were synthesized from podand 2-+,6-bis(2-formylphenoxymethyl)pyridine, with the γ-piperidone moiety having been constructed in the course of its domino condensation with simple ketones and ammonium acetate. The compounds were tested in vitro for antimicrobial and cytotoxic activity against four human cancer cell lines (Hep-G2, RD, MCF-7, Lu-1) and the Vero cell line. X-Ray structure study of one representative compound revealed its rac-1RS,23SR,24RS,26SR configuration.

Keywords: diazacrownophane, γ-piperidone, pyridine, cytotoxicity, antimicrobial, domino condensation.

Language: English

DOI: 10.1016/j.mencom.2020.11.021

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