A. E. Mekky, Sh. M. Sanad, “Synthesis and antibacterial evaluation of novel mono- and bis(2<i>H</i>-chromen-2-imine) hybrids linked to heteroarene units”, Mendeleev Commun., 2020, Volume 30, Issue 6,Pages <nobr>762

This article is cited in 13 papers

Communications

Synthesis and antibacterial evaluation of novel mono- and bis(2H-chromen-2-imine) hybrids linked to heteroarene units

A. E. Mekky, Sh. M. Sanad

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt

Abstract: Novel mono- and bis(2H-chromen-2-imine) hybrids linked to different heteroarene units were prepared by cyclocondensation of 2-hydroxybenzaldehydes with 2-heteroarylacetonitriles. Their in vitro antibacterial activities against different strains of Gram-positive and negative bacteria were assessed. Piperazine-linked bis(3-heteroaryl-2Hchromen-2-imines) exhibited the best antibacterial efficacies against E. coli, S. aureus and S. mutans strains with MIC values of 1.4–20.8μm.

Keywords: 2H-chromen-2-imines, benzo[f]chromen-3-imines, nitriles, salicylic aldehydes, hybrid molecules, heterocyclization, Knoevenagel reaction, antibacterial activity.

Language: English

DOI: 10.1016/j.mencom.2020.11.024

	*Supplementary materials:*
		Supplementary_data_1.pdf	4.0 Mb