S. R. Romanov, O. V. Orlova, M. P. Shulaeva, O. K. Pozdeev, A. P. Fedonin, K. A. Ivshin, O. N. Kataeva, I. V. Galkina, Yu. V. Bakhtiyarova, “Synthesis and antimicrobial activity of mono- and bisphosphonium salts based on tertiary phosphines and ethyl bromoacetate”, Mendeleev Commun., 2025, Volume 35, Issue 1,Pages <nobr>60

Communications

Synthesis and antimicrobial activity of mono- and bisphosphonium salts based on tertiary phosphines and ethyl bromoacetate

S. R. Romanov^a, O. V. Orlova^a, M. P. Shulaeva^ab, O. K. Pozdeev^b, A. P. Fedonin^a, K. A. Ivshin^c, O. N. Kataeva^c, I. V. Galkina^a, Yu. V. Bakhtiyarova^a

^a A. M. Butlerov Institute of Chemistry, Kazan Federal University, 420008 Kazan, Russian Federation
^b Kazan State Medical Academy, 420012 Kazan, Russian Federation
^c A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, 420088 Kazan, Russian Federation

Abstract: The nucleophilic substitution reaction between tertiary phosphines and ethyl bromoacetate affords the quaternary EtOC(O)CH₂-substituted phosphonium salts. In the cases of bisphosphines, the corresponding bisphosphonium salts are formed. The synthesized phosphonium compounds were evaluated for in vitro antimicrobial activity.

Keywords: quaternary phosphonium salts, tertiary phosphines, bromoacetates, antibacterial activity, antifungal activity.

Received: 27.06.2024
Accepted: 12.09.2024

Language: English

DOI: 10.71267/mencom.7560

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