P. A. Volkov, K. O. Khrapova, E. M. Vyi, A. A. Telezhkin, I. A. Bidusenko, A. I. Albanov, A. V. Shchepochkin, “Elemental sulfur as a trigger and reagent in cyclization of γ-amino acetylenic ketones to 1,2-dihydro-3<em>H</em>-pyrrole-3-thiones”, Mendeleev Commun., 2025, Volume 35, Issue 1,Pages <nobr>102

Communications

Elemental sulfur as a trigger and reagent in cyclization of γ-amino acetylenic ketones to 1,2-dihydro-3H-pyrrole-3-thiones

P. A. Volkov^a, K. O. Khrapova^a, E. M. Vyi^a, A. A. Telezhkin^a, I. A. Bidusenko^a, A. I. Albanov^a, A. V. Shchepochkin^b

^a A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russian Federation
^b I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620219 Ekaterinburg, Russian Federation

Abstract: An original and effective synthesis of 1,2-dihydro-3H-pyrrole-3-thiones from available γ-amino acetylenic ketones and elemental sulfur as a trigger and reagent has been developed. The reaction is carried out in the KOH/ethanol system, the yield of the target heterocycles being 46–75%.

Keywords: nucleophilic addition, heterocyclization, amino acetylenic ketones, 1,2-dihydro-3H-pyrrole-3-thiones, elemental sulfur, potassium hydroxide.

Received: 01.08.2024
Accepted: 12.09.2024

Language: English

DOI: 10.71267/mencom.7582

	*Supplementary materials:*
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