Mendeleev Commun., 2025 Volume 35, Issue 2, Pages 145–147
(Mi mendc1357)
Communications New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses O. A. Zhupikova a ,
O. I. Yarovaya a ,
M. K. Marenina a ,
Yu. V. Meshkova a ,
S. V. Belenkaya ab ,
D. N. Shcherbakov ab ,
A. V. Zaykovskaya b ,
O. V. Pyankov b ,
V. V. Zarubaev c ,
M. G. Mikhalsky c ,
A. Yu. Fedorov d ,
S. G. Arkhipov d ,
V. I. Potkin e ,
I. A. Kolesnik e ,
A. V. Ivanov f ,
N. F. Salakhutdinov a ,
M. V. Khvostov a a N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russian Federation b State Research Center of Virology and Biotechnology ‘Vector’, 630559 Koltsovo, Novosibirsk Region, Russian Federation c St. Petersburg Pasteur Institute, 197101 St. Petersburg, Russian Federationy d Institute of Chemical Technology, Novosibirsk State University, 630090 Novosibirsk, Russian Federation e Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus f A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russian Federation Abstract:
New thiosemicarbazones based on 5-arylisoxazole-3-carbaldehyde and substituted pyrrolecarbaldehydes have been obtained. The test for ability to inhibit the main viral protease 3Clpro of SARS-CoV-2 virus revealed a compound with activity against both corona- and influenza viruses.
Keywords:
thiosemicarbazones, isoxazoles, tetrahydroindoles, antiviral activity, protease 3Clpro, SARS-CoV-2 virus, influenza A (H1N1) virus, biological activity. Received: 25.07.2024
Accepted: 03.10.2024
Language: English
DOI:
10.71267/mencom.7578
© , 2025
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