X. He, J. Sui, J. Xu, Z. Wang, T. Yuan, D. Liu, L. Wang, Q. Zhu, “Mild cuprous halide mediated direct C<sup>3</sup> monohalogenation of indoles”, Mendeleev Commun., 2025, Volume 35, Issue 2,Pages <nobr>214

Communications

Mild cuprous halide mediated direct C³ monohalogenation of indoles

X. He^a, J. Sui^b, J. Xu^a, Z. Wang^a, T. Yuan^a, D. Liu^a, L. Wang^a, Q. Zhu^c

^a School of Chemical and Pharmaceutical Engineering, Changzhou Vocational Institute of Engineering, 213164 Changzhou, P.R. China
^b Nanjing Customs Testing Center for Dangerous Goods and Packaging, 213100 Changzhou, China
^c Department of Medicinal Chemistry, China Pharmaceutical University, 210009 Nanjing, China

Abstract: Treatment of indoles with cuprous halide–N-fluorobenzenesulfonimide system in MeCN at room temperature affords the corresponding C³-halogenated derivatives. Cuprous halide acts as a dual-function reagent serving both as the halogen source and the promoter.

Keywords: indole derivatives, halogenation, cuprous halide, N-fluorobenzenesulfonimide, mild conditions.

Received: 02.09.2024
Accepted: 16.10.2024

Language: English

DOI: 10.71267/mencom.7609

	*Supplementary materials:*
		Supplementary_data_1.pdf	5.1 Mb