V. V. Musiyak, D. A. Gruzdev, M. A. Kravchenko, D. V. Vakhrusheva, G. L. Levit, V. P. Krasnov, V. N. Charushin, “Synthesis and antimycobacterial activity of purine conjugates with (S)-lysine and (S)-ornithine”, Mendeleev Commun., 2019, Volume 29, Issue 1,Pages 11

This article is cited in 11 papers

Communications

Synthesis and antimycobacterial activity of purine conjugates with (S)-lysine and (S)-ornithine

V. V. Musiyak^a, D. A. Gruzdev^ab, M. A. Kravchenko^c, D. V. Vakhrusheva^c, G. L. Levit^ab, V. P. Krasnov^ab, V. N. Charushin^ab

^a I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
^b Institute of Chemical Engineering, Ural Federal University, Ekaterinburg, Russian Federation
^c Ural Research Institute for Phthisiopulmonology, Ekaterinburg, Russian Federation

Abstract: Novel purin-6-yl, 2-aminopurin-6-yl and N-(purin-6-yl)glycyl derivatives of (S)-lysine and (S)-ornithine with free α-functional groups, as well as compounds containing N⁹-(2-hydroxy-ethoxy)methyl substituent in the purine core have been synthesized and tested for their inhibitory effect against Mycobacterium tuberculosis strains. Among the synthesized conjugates, one compound exhibiting a significant level of antimycobacterial activity has been found.

Language: English

DOI: 10.1016/j.mencom.2019.01.002

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