D. V. Tsyganov, M. N. Semenova, L. D. Konyushkin, V. I. Ushkarov, M. M. Raihstat, V. V. Semenov, “A convenient synthesis of <i>cis</i>-restricted combretastatin analogues with pyrazole and isoxazole cores”, Mendeleev Commun., 2019, Volume 29, Issue 2,Pages <nobr>163

This article is cited in 16 papers

Communications

A convenient synthesis of cis-restricted combretastatin analogues with pyrazole and isoxazole cores

D. V. Tsyganov^a, M. N. Semenova^b, L. D. Konyushkin^a, V. I. Ushkarov^a, M. M. Raihstat^a, V. V. Semenov^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b N.K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: A series of combretastatin analogues, diarylpyrazoles and diarylisoxazoles, have been synthesized and evaluated for their antimitotic tubulin-binding activity using the phenotypic sea urchin (Paracentrotus lividus) embryo assay. One pyrazole analogue and four isoxazole analogues have been identified as potent antimitotic agents comparable with combretastatins A-2 and A-4, with the lowest observable effective concentration of 1–10nmoldm⁻³ for cleavage alteration of the test embryos.

Language: English

DOI: 10.1016/j.mencom.2019.03.015

	*Supplementary materials:*
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