A. T. Le, V. T. Tran, H. H. Truong, L. M. Nguyen, D. M. Luong, T. T. Do, D. T. Nguyen, N. T. Dao, D. T. Le, A. T. Soldatenkov, V. N. Khrustalev, “Synthesis and cytotoxicity of novel γ-piperidone-containing dibenzo-1,7-diaza-14-crown-4 ethers”, Mendeleev Commun., 2019, Volume 29, Issue 4,Pages <nobr>375

This article is cited in 13 papers

Communications

Synthesis and cytotoxicity of novel γ-piperidone-containing dibenzo-1,7-diaza-14-crown-4 ethers

A. T. Le^a, V. T. Tran^a, H. H. Truong^b, L. M. Nguyen^ac, D. M. Luong^a, T. T. Do^a, D. T. Nguyen^a, N. T. Dao^a, D. T. Le^a, A. T. Soldatenkov^b, V. N. Khrustalev^bd

^a Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Hoan Kiem, Hanoi, Vietnam
^b Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation
^c Faculty of Pharmacy, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen City, Vietnam
^d National Research Centre 'Kurchatov Institute', Moscow, Russian Federation

Abstract: For the development of new antitumor agents, novel dibenzo-1,7-diaza-14-crown-4 ethers containing γ-piperidone moiety were synthesized by a domino condensation of new podands, ketones and ammonium acetate. The crystal structure of one Ts of them was studied by X-ray diffraction. Four crown compounds were evaluated in vitro for cytotoxic activity against 5 human cancer cell lines.

Language: English

DOI: 10.1016/j.mencom.2019.07.004

	*Supplementary materials:*
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