Abstract:
Novel gemini (tail–head–spacer–head–tail) bis-quaternary ammonium compounds with a 4,4′-oxydiphenol spacer between two pyridinium heads were synthesized and compared with commonly used antiseptics such as benzalkonium chloride and chlorhexidine gluconate. Analogues bearing C8H17, C9H19 and C10H21 aliphatic groups displayed potent broad spectrum in vitro activity against five bacterial strains and two fungi, with minimum inhibtory concentrations relatively independent of the counter ion.