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JOURNALS // Mendeleev Communications // Archive

Mendeleev Commun., 2019 Volume 29, Issue 5, Pages 523–525 (Mi mendc1578)

This article is cited in 21 papers

Communications

Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer

A. N. Vereshchagina, N. A. Frolova, V. Yu. Konyuhovaab, K. A. Hansfordc, M. P. Egorova

a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
b D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
c Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia

Abstract: Novel gemini (tail–head–spacer–head–tail) bis-quaternary ammonium compounds with a 4,4′-oxydiphenol spacer between two pyridinium heads were synthesized and compared with commonly used antiseptics such as benzalkonium chloride and chlorhexidine gluconate. Analogues bearing C8H17, C9H19 and C10H21 aliphatic groups displayed potent broad spectrum in vitro activity against five bacterial strains and two fungi, with minimum inhibtory concentrations relatively independent of the counter ion.

Language: English

DOI: 10.1016/j.mencom.2019.09.015



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