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JOURNALS // Mendeleev Communications // Archive
Mendeleev Commun., 2019 Volume 29, Issue 5, Pages 526–528 (Mi mendc1579)
This article is cited in 1 paper

Communications

Synthesis of allobetulin-based asialoglycoprotein receptor-targeted glycoconjugates

E. I. Selezneva, E. Yu. Yamansarova, E. V. Lopatukhinaa, A. V. Lopuhova, D. A. Skvortsova, S. A. Evteeva, E. T. Yamansarovab, A. Yu. Adelgareevab, N. L. Klyachkoac, E. K. Beloglazkinaa, Ya. A. Ivanenkovde, A. G. Majougaafg

a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
b Department of Chemistry, Bashkir State University, Ufa, Russian Federation
c Skolkovo Institute of Science and Technology, Moscow, Russian Federation
d Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russian Federation
e Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow Region, Russian Federation
f D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
g National University of Science and Technology 'MISIS', Moscow, Russian Federation

Abstract: New allobetulin conjugates were obtained through its O-esterification with hex-5-ynoic acid followed by [3+2]-cycloaddition with three azido derivatives of N-acetyl-d-galactosamine. The conjugates are non-toxic in micromolar range against hepatocellular carcinoma cell lines and have a high affinity towards the HO asialoglycoprotein receptor of hepatocytes based on molecular docking and surface plasmon resonance data.

Language: English

DOI: 10.1016/j.mencom.2019.09.016


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