I. S. Popova, E. Yu. Korchagina, M. A. Sablina, A. S. Paramonov, A. K. Hult, S. M. Henry, N. V. Bovin, “Synthesis of blood group Forssman pentasaccharide GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glcβ–R”, Mendeleev Commun., 2019, Volume 29, Issue 5,Pages <nobr>578

This article is cited in 2 papers

Communications

Synthesis of blood group Forssman pentasaccharide GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glcβ–R

I. S. Popova^a, E. Yu. Korchagina^a, M. A. Sablina^a, A. S. Paramonov^a, A. K. Hult^b, S. M. Henry^c, N. V. Bovin^ac

^a M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden
^c School of Engineering, Computer & Mathematical Sciences, Auckland University of Technology, Auckland, New Zealand

Abstract: Synthesis of the glycan part of Forssman glycolipid GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glc–Cer in the form of 2-aminoethyl glycoside has been carried out. The glycoside has been converted into a lipophilic derivative capable of controlled inserting into erythrocytes. The obtained surface-modified cells, termed kodecytes, revealed a high level of the blood group system FORS serological activity.

Language: English

DOI: 10.1016/j.mencom.2019.09.034

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