K. A. Perevoshchikova, A. I. Nichugovskiy, A. K. Isagulieva, N. G. Morozova, I. V. Ivanov, M. A. Maslov, A. A. Shtil, “Synthesis of novel lipophilic tetraamines with cytotoxic activity”, Mendeleev Commun., 2019, Volume 29, Issue 6,Pages <nobr>616

This article is cited in 9 papers

Communications

Synthesis of novel lipophilic tetraamines with cytotoxic activity

K. A. Perevoshchikova^a, A. I. Nichugovskiy^a, A. K. Isagulieva^b, N. G. Morozova^a, I. V. Ivanov^a, M. A. Maslov^a, A. A. Shtil^b

^a M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation
^b N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation

Abstract: New lipophilic polyamines in which natural or synthetic tetraamines were linked via the terminal NH2 groups to diglycerides and/or to short-chained aliphatic substituents were synthesized, and their cytotoxic activity was tested. Relationship between the structure of the synthesized compounds and their cytotoxicity and hemolytic effect was evaluated.

Language: English

DOI: 10.1016/j.mencom.2019.11.003

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