M. P. Paramonova, A. A. Ozerov, A. O. Chizhov, R. Snoeck, G. Andrei, A. L. Khandazhinskaya, M. S. Novikov, “Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication”, Mendeleev Commun., 2019, Volume 29, Issue 6,Pages <nobr>638

This article is cited in 7 papers

Communications

Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication

M. P. Paramonova^a, A. A. Ozerov^a, A. O. Chizhov^b, R. Snoeck^c, G. Andrei^c, A. L. Khandazhinskaya^d, M. S. Novikov^a

^a Volgograd State Medical University, Volgograd, Russian Federation
^b N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^c Rega Institute for Medical Research, Leuven, Belgium
^d V.A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: A series of 1-[(bromophenoxy)alkyl]uracil–coumarin conjugates has been obtained through the preparation of starting 1-[(bromophenoxy)alkyl]uracil derivatives, followed by their treatment with 7-(ω-bromoalkoxy)-4-methyl-2H-chromen-2-ones. Two of the synthesized uracil–coumarin conjugates demonstrated a pronounced inhibitory activity against HCMV and VZV replication in vitro.

Language: English

DOI: 10.1016/j.mencom.2019.11.010

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