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JOURNALS // Mendeleev Communications // Archive
Mendeleev Commun., 2019 Volume 29, Issue 6, Pages 640–642 (Mi mendc1614)
This article is cited in 9 papers

Communications

Synthesis, structure and cytotoxicity of a zinc(II) bromide complex with caffeine

N. S. Rukka, L. G. Kuz'minab, G. A. Davydovac, G. A. Buzanovb, V. M. Retivovd, S. K. Belusd, E. I. Kozhukhovad, A. E. Barmashove, A. A. Khruleva, M. A. Simonovac, V. N. Krasnoperovaa

a M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation
b N.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
c Institute of Theoretical and Experimental Biophysics of RAS, Pushchino, Moscow region, Russian Federation
d Institute of Chemical Reagents and High Purity Chemical Substances, National Research Centre 'Kurchatov Institute', Moscow, Russian Federation
e N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation

Abstract: The synthesis and structure of a zinc(II) bromide complex with caffeine (caf), [Zn(caf)(H2O)Br2], are described in comparison with [Zn(caf)(H2O)X2] (X=Cl, I) complexes. Data on the cytotoxicity of [Zn(caf)(H2O)X2] (X=Cl, Br, I) towards human tumor cell lines are presented. The bromo complex has some advantages over chloro and iodo complexes for cytotoxicity on MCF-7 breast cancer cell line, and it is comparable to the chloro complex in cytotoxicity for Jurkat human T cell leukemia.

Language: English

DOI: 10.1016/j.mencom.2019.11.011



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