E. F. Sagitova, D. N. Tomilin, O. V. Petrova, A. B. Budaev, L. N. Sobenina, B. A. Trofimov, G. Q. Yang, R. Hu, “Acetylene based short route from 2,2,6,6-tetramethylpiperidin-4-one oxime to 2-(pyrazol-5-yl)-4,5,6,7-tetrahydropyrrolo[3,2-<i>c</i>]pyridines”, Mendeleev Commun., 2019, Volume 29, Issue 6,Pages <nobr>658

This article is cited in 2 papers

Communications

Acetylene based short route from 2,2,6,6-tetramethylpiperidin-4-one oxime to 2-(pyrazol-5-yl)-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridines

E. F. Sagitova^a, D. N. Tomilin^a, O. V. Petrova^a, A. B. Budaev^a, L. N. Sobenina^a, B. A. Trofimov^a, G. Q. Yang^b, R. Hu^b

^a A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Irkutsk, Russian Federation
^b Institute of Chemistry, Chinese Academy of Sciences, Beijing, China

Abstract: Pharmaceutically relevant substituted 2-(pyrazol-5-yl)-4,5,6,7-tetrahydropyrrolo [3,2-c]pyridines have been assembled in good to excellent yields via the reaction of 2,2,6,6-tetramethylpiperidin-4-one oxime with acetylene, cross-coupling of the resulting 4,4,6,6-tetramethyl-4,5,6,7 tetrahydropyrrolo[3,2-c]pyridines with aroylbromoacetylenes, and reaction of the formed 2-(aroylethynyl)-4,4,6,6-tetramethyl-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridines with hydrazine.

Language: English

DOI: 10.1016/j.mencom.2019.11.018

	*Supplementary materials:*
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