A. E. Ivanova, Ya. V. Burgart, V. I. Saloutin, Ya. R. Orshanskaya, V. V. Zarubaev, “β-d-Ribofuranosyl substituted polyfluoroalkylpyrazoles and their activity against the influenza virus”, Mendeleev Commun., 2018, Volume 28, Issue 1,Pages <nobr>52

This article is cited in 9 papers

Communications

β-d-Ribofuranosyl substituted polyfluoroalkylpyrazoles and their activity against the influenza virus

A. E. Ivanova^a, Ya. V. Burgart^a, V. I. Saloutin^a, Ya. R. Orshanskaya^b, V. V. Zarubaev^b

^a I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
^b A.A. Smorodintsev Research Institute of Influenza, St. Petersburg, Russian Federation

Abstract: Regiospecific ribosylation of 3-polyfluoroalkyl-5-phenylpyrazoles with 1,2,3,5-tetra-O-acetyl-β-d-ribofuranose in the presence of tin(iv) chloride followed by deacetylation affords 1-(β-d-ribofuranosyl)-3-polyfluoroalkyl-5-phenyl- 1H-pyrazoles. These derivatives as well as starting pyrazoles were tested for anti-influenza activity.

Language: English

DOI: 10.1016/j.mencom.2018.01.017