I. Yu. Nagaev, K. V. Shevchenko, V. P. Shevchenko, N. F. Myasoedov, V. V. Grigoriev, M. I. Lavrov, E. V. Bondarenko, E. E. Kalashnikova, “Synthesis of tritium-labeled PAM-43”, Mendeleev Commun., 2018, Volume 28, Issue 1,Pages <nobr>64–65</nobr>

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Mendeleev Commun., 2018 Volume 28, Issue 1, Pages 64–65 (Mi mendc1665)

This article is cited in 5 papers

Communications

Synthesis of tritium-labeled PAM-43

I. Yu. Nagaev^a, K. V. Shevchenko^a, V. P. Shevchenko^a, N. F. Myasoedov^a, V. V. Grigoriev^b, M. I. Lavrov^c, E. V. Bondarenko^d, E. E. Kalashnikova^d

^a Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^c Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^d “Cyclomemorin” LTD, 249030 Obninsk, Kaluga region, Russian Federation

Abstract: The deuterium- and tritium-labeled PAM-43 was obtained in 23% yield and with a specific radioactivity of 132 Ci mmol^–1. As determined by mass spectrometry, a PAM-43 molecule contained 80% of deuterium in 2,3-dihydrobenzofuran fragments, while the central fragment contained 20% of deuterium.

Language: English

DOI: 10.1016/j.mencom.2018.01.021

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