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JOURNALS // Mendeleev Communications // Archive

Mendeleev Commun., 2018 Volume 28, Issue 2, Pages 131–132 (Mi mendc1687)

This article is cited in 4 papers

Communications

Novel azetidinones for carbapenems and fragmentation in the allylamine precursor analogue

N. K. Selezneva, Z. R. Valiullina, L. S. Khasanova, F. A. Gimalova, R. Z. Biglova, M. S. Miftakhov

Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation

Abstract: (2R,3R)-N-(3-Methoxy-2,3-dioxopropyl)-N-(4-methoxy-phenyl)-2,3-epoxybutanamide on treatment with strong bases (LDA, LHMDS) gives 3-[(1R)-1-hydroxyethyl]azetidin-2-one derivative, while the N-(3-methoxy-2-methylidene-3-oxo-propyl) analogue undergoes fragmentation.

Language: English

DOI: 10.1016/j.mencom.2018.03.005



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