A. A. Smirnova, E. V. Tretyakova, O. B. Kazakova, “Inhibiting the cancer cell growth by maleopimarate amino imide bis-tetrazoles synthesized <i>via</i> the azido-Ugi reaction”, Mendeleev Commun., 2024, Volume 34, Issue 4,Pages <nobr>509

This article is cited in 2 papers

Communications

Inhibiting the cancer cell growth by maleopimarate amino imide bis-tetrazoles synthesized via the azido-Ugi reaction

A. A. Smirnova, E. V. Tretyakova, O. B. Kazakova

Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation

Abstract: The azido-Ugi reaction of methyl maleopimarate N-(2- aminoethyl) imide with isocyanides, paraformaldehyde and trimethylsilyl azide in one step leads to 1,5-disubstituted diterpene bis-tetrazoles. The compounds demonstrate selective cytotoxicity against NCI-60 cancer cell panel.

Keywords: azido-Ugi reaction, isocyanides, tetrazoles, abietane diterpenes, methyl maleopimarate, amino imides, anticancer activity.

Language: English

DOI: 10.1016/j.mencom.2024.06.012

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