A. A. Yaroslavov, A. A. Efimova, F. D. Mulashkin, G. N. Rudenskaya, G. G. Krivtsov, “Biodegradable liposome–chitosan complexes: enzyme-mediated release of encapsulated substances”, Mendeleev Commun., 2018, Volume 28, Issue 2,Pages <nobr>140

This article is cited in 15 papers

Communications

Biodegradable liposome–chitosan complexes: enzyme-mediated release of encapsulated substances

A. A. Yaroslavov^a, A. A. Efimova^a, F. D. Mulashkin^a, G. N. Rudenskaya^a, G. G. Krivtsov^b

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russian Federation

Abstract: Multi-liposomal containers were prepared via electrostatic adsorption of 50 nm anionic liposomes on the surface of cationic chitosan nanoparticles (nanogels) 270 nm in diameter. The containers are stable in aqueous-salt solutions but degrade in the presence of proteolytic enzymes down to 10–15 nm particles and release water-soluble substances encapsulated into the adsorbed liposomes. Based on the kinetic data, the mechanism of the release is discussed.

Language: English

DOI: 10.1016/j.mencom.2018.03.009

	*Supplementary materials:*
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