A. V. Vinyukov, A. V. Borodachev, A. S. Starikov, A. V. Afanasyev, M. E. Dmitriev, B. V. Lednev, V. V. Ragulin, “An efficient one-pot synthesis of bis(α-aminoalkyl)phosphinic acids, phosphorus-isosteric analogues of HIV protease inhibitors”, Mendeleev Commun., 2018, Volume 28, Issue 3,Pages <nobr>295

This article is cited in 2 papers

Communications

An efficient one-pot synthesis of bis(α-aminoalkyl)phosphinic acids, phosphorus-isosteric analogues of HIV protease inhibitors

A. V. Vinyukov, A. V. Borodachev, A. S. Starikov, A. V. Afanasyev, M. E. Dmitriev, B. V. Lednev, V. V. Ragulin

Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Abstract: An acid-catalyzed three-component reaction between hypophosphorous acid, aldehydes and alkyl carbamates under mild conditions afforded bis(α-aminoalkyl)phosphinic acids. The proposed facile single-stage protocol is prospective for expansion of a range of phosphinic analogues of HIV protease inhibitors.

Language: English

DOI: 10.1016/j.mencom.2018.05.022