M. N. Elinson, A. N. Vereshchagin, Yu. E. Anisina, A. S. Goloveshkin, I. E. Ushakov, M. P. Egorov, “PASE facile and efficient multicomponent approach to the new type of 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold”, Mendeleev Commun., 2018, Volume 28, Issue 4,Pages <nobr>372

This article is cited in 16 papers

Communications

PASE facile and efficient multicomponent approach to the new type of 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold

M. N. Elinson^a, A. N. Vereshchagin^a, Yu. E. Anisina^a, A. S. Goloveshkin^b, I. E. Ushakov^b, M. P. Egorov^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation

Abstract: The new multicomponent reaction comprises the triethylamine catalyzed assembling of salicylaldehydes, 2-aminoprop- 1-ene-1,1,3-tricarbonitrile and 3-methyl-2-pyrazolin-5-one in small amount of propanol, which affords substituted 2,4-diamino-5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitriles in 63–98% yields. This process is in agreement with PASE principles and opens the way to new chromeno[2,3-b]pyridine scaffold containing 3-methyl-2-pyrazolin-5-one fragment, which is promising for various biomedical applications.

Language: English

DOI: 10.1016/j.mencom.2018.07.010

	*Supplementary materials:*
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