G. V. Pazynina, S. V. Tsygankova, I. M. Ryzhov, A. S. Paramonov, N. V. Bovin, “Synthesis of H (type 4) trisaccharide, key structural fragment of globo-H and fucosyl-GM1 cancer-associated antigens”, Mendeleev Commun., 2018, Volume 28, Issue 4,Pages <nobr>421

This article is cited in 2 papers

Communications

Synthesis of H (type 4) trisaccharide, key structural fragment of globo-H and fucosyl-GM1 cancer-associated antigens

G. V. Pazynina, S. V. Tsygankova, I. M. Ryzhov, A. S. Paramonov, N. V. Bovin

M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: A convenient synthesis of Fucα1-2Galβ1-3GalNAcβ-OCH₂CH₂CH₂NH₂ (trisaccharide H type 4) is described. This glycan is the terminal part of glycosphingolipids globo-H and fucosyl-GM1 known as cancer-associated carbohydrate antigens.

Language: English

DOI: 10.1016/j.mencom.2018.07.027