K. N. Sedenkova, E. B. Averina, A. A. Nazarova, Yu. K. Grishin, D. S. Karlov, V. L. Zamoyski, V. V. Grigoriev, T. S. Kuznetsova, V. A. Palyulin, “The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold”, Mendeleev Commun., 2018, Volume 28, Issue 4,Pages <nobr>423–425</nobr>

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Mendeleev Commun., 2018 Volume 28, Issue 4, Pages 423–425 (Mi mendc1788)

This article is cited in 14 papers

Communications

The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold

K. N. Sedenkova^ab, E. B. Averina^ab, A. A. Nazarova^a, Yu. K. Grishin^a, D. S. Karlov^ab, V. L. Zamoyski^b, V. V. Grigoriev^ab, T. S. Kuznetsova^a, V. A. Palyulin^ab

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Abstract: A convenient approach to novel symmetric bispyrimidine diamines comprises S_NAr reactions of 4-fluoropyrimidine N-oxide with alkane-α,ω-diamines with subsequent reduction of N-oxide function. The obtained substances were tested in patch-clamp experiments for the influence on the kainateinduced currents in Purkinje neurons and showed negative modulating effect.

Language: English

DOI: 10.1016/j.mencom.2018.07.028

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