A. V. Astakhov, K. Yu. Suponitsky, V. M. Chernyshev, “Chlorotrimethylsilane-promoted synthesis of 1,2,4-triazolopyrimidines from 3,5-diamino-1,2,4-triazoles and pentane-2,4-diones”, Mendeleev Commun., 2018, Volume 28, Issue 4,Pages <nobr>439

This article is cited in 9 papers

Communications

Chlorotrimethylsilane-promoted synthesis of 1,2,4-triazolopyrimidines from 3,5-diamino-1,2,4-triazoles and pentane-2,4-diones

A. V. Astakhov^a, K. Yu. Suponitsky^b, V. M. Chernyshev^a

^a Platov South-Russian State Polytechnic University, Novocherkassk, Russian Federation
^b A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation

Abstract: An efficient synthesis of 2-amino-1-R-[1,2,4]triazolo[1,5-a]-pyrimidinium or 3-amino-2-R-[1,2,4]triazolo[4,3-a]pyrimidi- nium chloride derivatives by heterocyclization of 3,5-diamino-1-R-1,2,4-triazoles (R=Alk or Ar) with pentane-2,4-diones was developed. The process is promoted by chlorotrimethyl- silane which plays the dual role of carbonyl-activating agent and water scavenger.

Language: English

DOI: 10.1016/j.mencom.2018.07.034

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