M. A. Khomutov, M. T. Hyvönen, A. R. Simonian, J. Weisell, J. J. Vepsalainen, L. Alhonen, S. N. Kochetkov, T. A. Keinanen, A. R. Khomutov, “Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase”, Mendeleev Commun., 2018, Volume 28, Issue 5,Pages 479

This article is cited in 5 papers

Communications

Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N¹-acetylpolyamine oxidase

M. A. Khomutov^a, M. T. Hyvönen^b, A. R. Simonian^a, J. Weisell^b, J. J. Vepsalainen^b, L. Alhonen^b, S. N. Kochetkov^a, T. A. Keinanen^b, A. R. Khomutov^a

^a V.A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation
^b School of Pharmacy, Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland

Abstract: The title compounds were prepared in high overall yields from properly protected (Boc, Cbz) 2- , 3- or 8-methyl-4-azaoctane-1,8-diamines. N¹-Acetyl-2-methyl- and N¹-acetyl-8-methylspermidines, but not N¹-acetyl-3-methylspermidine, were the substrates for N¹-acetylpolyamine oxidase.

Language: English

DOI: 10.1016/j.mencom.2018.09.008