K. E. Metlushka, D. N. Sadkova, K. A. Nikitina, Z. R. Yamaleeva, K. A. Ivshin, O. N. Kataeva, V. A. Alfonsov, “A new synthetic route to chiral 3-aryl-5-ethyl-1,4,2-oxazaphosphorines”, Mendeleev Commun., 2018, Volume 28, Issue 6,Pages <nobr>579

This article is cited in 5 papers

Communications

A new synthetic route to chiral 3-aryl-5-ethyl-1,4,2-oxazaphosphorines

K. E. Metlushka^a, D. N. Sadkova^a, K. A. Nikitina^a, Z. R. Yamaleeva^a, K. A. Ivshin^ab, O. N. Kataeva^a, V. A. Alfonsov^a

^a A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russian Federation
^b A.M. Butlerov Chemistry Institute, Kazan Federal University, Kazan, Russian Federation

Abstract: Diastereoselective synthesis of racemic and enantiopure 3-aryl-5-ethyl-1,4,2-oxazaphosphorines, including those bearing phenolic hydroxyl groups in the exocyclic aromatic fragment, was implemented by the reaction of imines derived from (±)-and (R)-(−)-2-aminobutan-1-ol and (hydroxy)benzaldehydes with triethyl phosphite and trifluoroacetic acid, followed by the one-pot dealkylation of the intermediate esters.

Language: English

DOI: 10.1016/j.mencom.2018.11.004

	*Supplementary materials:*
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