M. A. Gradova, I. I. Ostashevskaya, O. V. Gradov, A. V. Lobanov, V. S. Lebedeva, A. F. Mironov, “Photophysical properties and photodynamic activity of 13,15-N-methoxy-cycloimide chlorin p6 methyl ester in micellar surfactant solutions”, Mendeleev Commun., 2018, Volume 28, Issue 6,Pages 589

This article is cited in 6 papers

Communications

Photophysical properties and photodynamic activity of 13,15-N-methoxy-cycloimide chlorin p₆ methyl ester in micellar surfactant solutions

M. A. Gradova^a, I. I. Ostashevskaya^a, O. V. Gradov^ab, A. V. Lobanov^a, V. S. Lebedeva^c, A. F. Mironov^c

^a N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation
^b V.L. Talrose Institute of Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russian federation
^c M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation

Abstract: Photophysical parameters, photostability, aggregation behavior and photochemical activity of a new chlorin p₆-based photosensitizer in micellar surfactant solutions were estimated. Despite the low fluorescence quantum yields, this compound demonstrates high photostability, and its photodynamic activity in micellar systems is comparable to that of the commercial photosensitizer Fotoditazin^®, which makes this chlorin p₆ derivative suitable for the interstitial photodynamic therapy of solid tumors.

Language: English

DOI: 10.1016/j.mencom.2018.11.008