K. N. Sedenkova, A. A. Nazarova, E. V. Khvatov, E. V. Dueva, A. A. Orlov, D. I. Osolodkin, Yu. K. Grishin, T. S. Kuznetsova, V. A. Palyulin, E. B. Averina, “A facile metal-free approach to <i>N</i>,<i>N</i>′-bis(1-oxidopyrimidin-4-yl)diamines with promising biological activity”, Mendeleev Commun., 2018, Volume 28, Issue 6,Pages <nobr>592–594</nobr>

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Mendeleev Commun., 2018 Volume 28, Issue 6, Pages 592–594 (Mi mendc1846)

This article is cited in 12 papers

Communications

A facile metal-free approach to N,N′-bis(1-oxidopyrimidin-4-yl)diamines with promising biological activity

K. N. Sedenkova^ab, A. A. Nazarova^a, E. V. Khvatov^c, E. V. Dueva^ac, A. A. Orlov^ac, D. I. Osolodkin^acd, Yu. K. Grishin^a, T. S. Kuznetsova^a, V. A. Palyulin^ab, E. B. Averina^ab

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^c M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitis, Moscow, Russian Federation
^d I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

Abstract: Novel N-(1-oxidopyrimidin-4-yl)- and N,N′-bis(1-oxidopyrimidin-4-yl)diamines were prepared from 4-fluoropyrimidine N-oxides and diamines basing on S_NAr reaction. One compound from this series possessed antiviral activity against tick-borne encephalitis virus (TBEV).

Language: English

DOI: 10.1016/j.mencom.2018.11.009

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