A. S. Kulikov, M. A. Epishina, A. I. Churakov, L. V. Anikina, L. L. Fershtat, N. N. Makhova, “Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans”, Mendeleev Commun., 2018, Volume 28, Issue 6,Pages <nobr>623–625</nobr>

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Mendeleev Commun., 2018 Volume 28, Issue 6, Pages 623–625 (Mi mendc1857)

This article is cited in 14 papers

Communications

Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans

A. S. Kulikov^a, M. A. Epishina^a, A. I. Churakov^ab, L. V. Anikina^c, L. L. Fershtat^a, N. N. Makhova^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^c Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Abstract: The effective and regioselective synthesis of new (2-hydrazinylthiazol-4-yl)furoxan hydrobromides based on the condensation of (bromoacetyl)furoxans with thiosemicarbazide has been developed. The cytotoxic activity of their derivatives (with hydrazone, 4-thiazolo[2.3-c][1,2,4]triazole or pyrrole moieties) against two human cancer cell lines (A549, HCT116) was tested and several structures revealed moderate cytotoxic activity.

Language: English

DOI: 10.1016/j.mencom.2018.11.020

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