aSchool of Chemical and Pharmaceutical Engineering, Changzhou Vocational Institute of Engineering, Changzhou, P.R. China bSchool of Petrochemical Engineering, Changzhou University, Changzhou, China
Abstract:
A 100% atom-efficient thia-Michael addition process between thiols and α,β -unsaturated carbonyl compounds in a Brønsted acidic deep eutectic solvent at room temperature has been developed. The medium, choline chloride/p-toluene- sulfonic acid, not only showed good catalytic activity, but also could be readily recovered and reused with slight decrease in its activity after successive five runs.
Keywords:thia-Michael addition, C–S bond formation, sulfides, α,β-unsaturated carbonyl compounds, deep eutectic solvent, atom economy, green chemistry.
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