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JOURNALS // Mendeleev Communications // Archive

Mendeleev Commun., 2017 Volume 27, Issue 1, Pages 82–84 (Mi mendc1903)

This article is cited in 8 papers

Communications

Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity

V. V. Abzianidzea, K. P. Bolshakovab, D. S. Prokofievaa, A. O. Berestetskiyc, V. A. Kuznetsova, Yu. G. Trishinb

a Research Institute of Hygiene, Occupational Pathology and Human Ecology, Leningrad region, Russian Federation
b Saint-Petersburg State University of Industrial Technologies and Design, St. Petersburg, Russian Federation
c All-Russian Institute of Plant Protection, Federal Agency of Scientific Organizations, Pushkin, St. Petersburg, Russian Federation

Abstract: The herein synthesized 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A have lower cytotoxic activity towards the human lung adenocarcinoma A549 cell line compared to phaeosphaeride A. The presence of exocyclic C=C bond and N–OMe group in such compounds is suggested to be a factor in their antitumor activity.

Language: English

DOI: 10.1016/j.mencom.2017.01.026



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