N. S. Vostrikov, I. F. Lobko, L. V. Spirikhin, Yu. V. Vakhitova, K. K. Pivnitsky, M. S. Miftakhov, “Side-modified 15-deoxy-Δ<sup>12,14</sup>-prostaglandin D<sub>2</sub>, precursor of corresponding PGJ<sub>2</sub>. Synthesis from cloprostenol and anticancer activity”, Mendeleev Commun., 2017, Volume 27, Issue 2,Pages <nobr>125–127</nobr>

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Mendeleev Commun., 2017 Volume 27, Issue 2, Pages 125–127 (Mi mendc1917)

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Communications

Side-modified 15-deoxy-Δ^12,14-prostaglandin D₂, precursor of corresponding PGJ₂. Synthesis from cloprostenol and anticancer activity

N. S. Vostrikov^a, I. F. Lobko^a, L. V. Spirikhin^a, Yu. V. Vakhitova^b, K. K. Pivnitsky^c, M. S. Miftakhov^a

^a Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation
^b Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russian Federation
^c N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: The title compound, a possible precursor of metabolically stable corresponding PGJ₂, was obtained from cloprostenol in seven steps. The compound demonstrated cytotoxicity against the HEK 293, Hep G2 and Jurkat cell lines.

Language: English

DOI: 10.1016/j.mencom.2017.03.005

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