D. A. Vasilenko, E. B. Averina, N. A. Zefirov, B. Wobith, Yu. K. Grishin, V. B. Rybakov, O. N. Zefirova, T. S. Kuznetsova, S. A. Kuznetsov, N. S. Zefirov, “Synthesis and antimitotic activity of novel 5-aminoisoxazoles bearing alkoxyaryl moieties”, Mendeleev Commun., 2017, Volume 27, Issue 3,Pages <nobr>228

This article is cited in 19 papers

Communications

Synthesis and antimitotic activity of novel 5-aminoisoxazoles bearing alkoxyaryl moieties

D. A. Vasilenko^a, E. B. Averina^ab, N. A. Zefirov^a, B. Wobith^c, Yu. K. Grishin^a, V. B. Rybakov^a, O. N. Zefirova^ab, T. S. Kuznetsova^a, S. A. Kuznetsov^c, N. S. Zefirov^ab

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^c Institute of Biological Sciences, Cell Biology and Biosystems Technology, University of Rostock, Rostock, Germany

Abstract: 5-Aminoisoxazoles containing trimethoxy- and methylenedioxyphenyl moieties were prepared by heterocyclization of electrophilic alkenes with tetranitromethane in the presence of triethylamine with subsequent reduction of resulting 5-nitroisoxazoles. The crystal structure of 3,4,5-trimethoxybenzyl 5-aminoisoxazole-3-carboxylate was determined by X-ray analysis. Two novel 5-aminoisoxazoles demonstrated moderate antimitotic activity to human lung carcinoma A549 cell line.

Language: English

DOI: 10.1016/j.mencom.2017.05.003

	*Supplementary materials:*
		Supplementary_data_1.pdf	1.9 Mb