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JOURNALS // Mendeleev Communications // Archive

Mendeleev Commun., 2017 Volume 27, Issue 3, Pages 299–301 (Mi mendc1975)

This article is cited in 8 papers

Communications

An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship

A. A. Yaroslavova, A. A. Efimovaa, G. N. Rudenskayaa, N. S. Melik-Nubarova, I. D. Grozdovaa, A. A. Ezhovb, S. N. Chvalunc, A. I. Kulebyakinac, E. V. Kuznetsovac

a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
b Department of Physics, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
c National Research Centre 'Kurchatov Institute', Moscow, Russian Federation

Abstract: A low-toxic ternary complex composed of anionic liposomes, cationic polylysine and slightly negative micelles from a polylactide– polyethylene glycol diblock copolymer is described. Liposomes with the encapsulated antitumor antibiotic Doxorubicin (Dox) retain their integrity after incorporation into the ternary complex. The incubation of cells with the Dox-loaded ternary complex leads to its penetration into the cells, the release of Dox from liposomes and predominant drug accumulation in cell nuclei. The ternary complex degrades to nanoparticles in the presence of proteolytic enzymes to produce low-toxic digestion products.

Language: English

DOI: 10.1016/j.mencom.2017.05.028



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