M. S. Gaman, E. S. Matyugina, M. S. Novikov, D. A. Babkov, P. N. Solyev, S. N. Kochetkov, A. L. Khandazhinskaya, “New benzophenone phosphonate derivatives”, Mendeleev Commun., 2017, Volume 27, Issue 4,Pages <nobr>346

This article is cited in 2 papers

Communications

New benzophenone phosphonate derivatives

M. S. Gaman^a, E. S. Matyugina^a, M. S. Novikov^b, D. A. Babkov^b, P. N. Solyev^a, S. N. Kochetkov^a, A. L. Khandazhinskaya^a

^a V.A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation
^b Volgograd State Medical University, Volgograd, Russian Federation

Abstract: New well-soluble in 10% DMSO phosphonate derivatives of substituted benzophenone have been synthesized using different methods. Preliminary computer modeling of proposed structures in the reverse transcriptase HIV-1 hydrophobic pocket suggested these molecules as potential non-nucleoside inhibitors of this enzyme.

Language: English

DOI: 10.1016/j.mencom.2017.07.008

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