D. O. Prima, E. V. Vorontsova, A. G. Makarov, A. Yu. Makarov, I. Yu. Bagryanskaya, T. F. Mikhailovskaya, Yu. G. Slizhov, A. V. Zibarev, “Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis”, Mendeleev Commun., 2017, Volume 27, Issue 5,Pages <nobr>439

This article is cited in 19 papers

Communications

Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis

D. O. Prima^ab, E. V. Vorontsova^c, A. G. Makarov^a, A. Yu. Makarov^a, I. Yu. Bagryanskaya^ad, T. F. Mikhailovskaya^a, Yu. G. Slizhov^b, A. V. Zibarev^ab

^a N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
^b Department of Chemistry, National Research Tomsk State University, Tomsk, Russian Federation
^c Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russian Federation
^d Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russian Federation

Abstract: The title compounds synthesized from halogenated arene-1,2-diamines revealed, together with the latter, cytotoxicity towards the Hep2 (laryngeal epidermoid carcinoma) cells. The cytotoxicity was high and was accompanied by pronounced apoptotic activity at low concentrations for fluorinated diazoles, triazoles and selenadiazoles.

Language: English

DOI: 10.1016/j.mencom.2017.09.002

	*Supplementary materials:*
		Supplementary_data_1.pdf	795.4 Kb