I. V. Mikhura, A. A. Formanovsky, E. V. Nozhevnikova, I. A. Prokhorenko, V. A. Korshun, “Dianhydrides of 1(4)-substituted 7,8-diphenylbicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxylic acids”, Mendeleev Commun., 2017, Volume 27, Issue 5,Pages <nobr>446

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Communications

Dianhydrides of 1(4)-substituted 7,8-diphenylbicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxylic acids

I. V. Mikhura^a, A. A. Formanovsky^a, E. V. Nozhevnikova^a, I. A. Prokhorenko^ab, V. A. Korshun^ab

^a M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b G.F. Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow, Russian Federation

Abstract: 2(5)-Substituted 4-hydroxy-3,4-diphenylcyclopent-2-en-1-ones easily react with 2.5 molar excess of maleic anhydride to give 1(4)-substituted 7,8-diphenylbicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxylic acid dianhydrides containing alkyl groups at bridgehead of the bicycle. The stereochemistry of the obtained bicyclic bis-anhydrides was determined to be syn-syn.

Language: English

DOI: 10.1016/j.mencom.2017.09.004