S. A. Tishina, V. S. Stroylov, I. A. Zanyatkin, A. K. Melnikova, V. I. Muronetz, Yu. Yu. Stroylova, “Cinnamic acid derivatives as the potential modulators of prion aggregation”, Mendeleev Commun., 2017, Volume 27, Issue 5,Pages <nobr>493

This article is cited in 7 papers

Communications

Cinnamic acid derivatives as the potential modulators of prion aggregation

S. A. Tishina^a, V. S. Stroylov^b, I. A. Zanyatkin^a, A. K. Melnikova^a, V. I. Muronetz^ac, Yu. Yu. Stroylova^cd

^a Department of Bioengineering and Bioinformatics, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^c A.N. Belozersky Research Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^d Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

Abstract: Eight cinnamic acid derivatives were studied as prion inhibitors in vitro and their cytotoxicity was evaluated. Ferulic (3-methoxy-4-hydroxycinnamic) acid, 3,4,5-trimethoxycin- namic acid and methyl 3-ethoxy-4-acetamidoxycinnamate were found to inhibit amyloid fibril formation, seeding, and spontaneous aggregation of recombinant ovine prion protein. None of the compounds demonstrated cytotoxicity on human neuroblastoma SH-SY5Y cells.

Language: English

DOI: 10.1016/j.mencom.2017.09.021