D. A. Gruzdev, E. N. Chulakov, G. L. Levit, M. A. Kravchenko, V. P. Krasnov, V. N. Charushin, “Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with (S)-aspartic and (S)-glutamic acids”, Mendeleev Commun., 2017, Volume 27, Issue 6,Pages 547

This article is cited in 15 papers

Communications

Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with (S)-aspartic and (S)-glutamic acids

D. A. Gruzdev^a, E. N. Chulakov^a, G. L. Levit^a, M. A. Kravchenko^b, V. P. Krasnov^a, V. N. Charushin^a

^a I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
^b Ural Research Institute for Phthisiopulmonology, Ekaterinburg, Russian Federation

Abstract: Novel purine and 2-aminopurine conjugates containing fragments of (S)-aspartic and (S)-glutamic acids with free α-functional groups attached via a 1,2-ethylenediamine linker at 6-position of the purine core, as well as their analogues with N⁹-(2-hydroxyethoxy)methyl substituent have been synthesized. Among the conjugates obtained, compounds exhibiting a significant antimycobacterial activity have been found.

Language: English

DOI: 10.1016/j.mencom.2017.11.002

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