O. O. Koloskova, A. S. Nosova, I. S. Shchelik, I. P. Shilovskiy, Yu. L. Sebyakin, M. R. Khaitov, “Liver-targeted delivery of nucleic acid by liposomes modified with a glycoconjugate”, Mendeleev Commun., 2017, Volume 27, Issue 6,Pages <nobr>626

This article is cited in 8 papers

Communications

Liver-targeted delivery of nucleic acid by liposomes modified with a glycoconjugate

O. O. Koloskova^ab, A. S. Nosova^ab, I. S. Shchelik^b, I. P. Shilovskiy^a, Yu. L. Sebyakin^b, M. R. Khaitov^a

^a State Research Center 'Institute of Immunology', Federal Medico-Biological Agency, Moscow, Russian Federation
^b M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation

Abstract: A drug delivery system based on liposomes has been modified by targeted vectors based on a glycoconjugate, and the vector structure has been optimized. The glycoconjugate in liposomes almost fourfold increases the transfection efficiency of the delivery system in specific human liver cell line (HepG2) in comparison with that of unmodified lipopeptide-based liposomes.

Language: English

DOI: 10.1016/j.mencom.2017.11.030