M. G. Khrenova, I. D. Solovyev, V. N. Azev, G. D. Lapshin, A. P. Savitsky, “Oxoethylene derivative of the natural substrate as an inhibitor of matrix metalloproteinase MMP-2”, Mendeleev Commun., 2016, Volume 26, Issue 3,Pages <nobr>207

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Communications

Oxoethylene derivative of the natural substrate as an inhibitor of matrix metalloproteinase MMP-2

M. G. Khrenova^ab, I. D. Solovyev^ab, V. N. Azev^c, G. D. Lapshin^b, A. P. Savitsky^b

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russian Federation
^c Branch of M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow Region, Russian Federation

Abstract: A mimetic of a natural substrate of the matrix metalloproteinase MMP-2, in which the amide group with the scissile peptide bond is replaced with the oxoethylene moiety, inhibits the enzyme.

Language: English

DOI: 10.1016/j.mencom.2016.04.009