Amyloid-β containing isoaspartate 7 as potential biomarker and drug target in Alzheimer's disease

Recent data about structure, interaction with biometals, aggregation state, proteolysis by angiotensin converting enzyme, neurotoxicity and amyloidogenicity of amyloid-β containing isoaspartate 7 (isoAsp7-Aβ) in comparison with intact amyloid-β are summarized. Possible role of isoAsp7-Aβ as a prospective biomarker for molecular diagnostics and drug target in anti-amyloid therapy of Alzheimer's disease is discussed.