V. L. Lvov, A. V. Filatov, A. V. Perepelov, A. M. Shpirt, A. S. Shashkov, A. O. Chizhov, Yu. A. Knirel, “Solvolysis with trifluoroacetic acid: an efficient method for selective cleavage of polysaccharides”, Mendeleev Commun., 2016, Volume 26, Issue 4,Pages <nobr>279

This article is cited in 12 papers

Communications

Solvolysis with trifluoroacetic acid: an efficient method for selective cleavage of polysaccharides

V. L. Lvov^a, A. V. Filatov^b, A. V. Perepelov^b, A. M. Shpirt^b, A. S. Shashkov^b, A. O. Chizhov^b, Yu. A. Knirel^b

^a State Research Center 'Institute of Immunology', Federal Medico-Biological Agency, Moscow, Russian Federation
^b N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Solvolysis of polysaccharides with trifluoroacetic acid is efficient for selective cleavage of certain glycosidic linkages. This method was successfully used for structure elucidation of polysaccharides and obtaining oligosaccharides from polysaccharides for construction of glycoconjugate vaccines in cases of O-specific polysaccharides of bacteria Enterobacter cloacae and Shigella flexneri.

Language: English

DOI: 10.1016/j.mencom.2016.07.003